Knowing the shape of proteins is crucial for our understanding of human health and for developing new drugs. To do this current methods require proteins to be dissolved in a solution or locked in a crystal lattice. These approaches are incredibly powerful and are the mainstay of the field of structural biology as we know it. But what about the third phase? How would proteins survive once they have gone beyond solid and solution phases and released into the atmosphere?
While many scientists thought that proteins would no longer maintain their shape in the vapour phase Carol Robinson embarked on eccentric research into studying proteins freely moving within in this phase. This work proved to be unpredictably worthwhile, and her gas phase structural biology is now providing a new view of dynamic interactions between proteins, lipids and drugs.
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16-17
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